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Zinc is an essential trace element Zinc is an essential trace element required for function of many metalloproteases and transcription factors involved in reproduction, immunology, and wound repair

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Neonatal lethality in severe cases , if not treated early

A number of cases complained of irritation or desquamation while only 2 cases complained of vesicles in the TCA groups that faded with no other serious events recorded

Data availability Parts of the FCH cohort were previously published under the accession numbers MK092096-MK092105 (FCH1-5) [ MK092106-MK092111 (Non-FCH1-3) [ OM222702 (GLT1) [ HQ719473 (BHCV1) [ and JQ914274 (1a_FCH2) [ Sequence information on all other FCH patients generated during this study is deposited in GenBank under the following accessions: PV083181-PV083206 [ PX390011-PX390139 [ NGS data from the GLT1 patient are deposited in the sequence read archive (SRA) under the BioProject accession PRJNA1214216

The tanning response is, in reality, a physiological repair mechanism to instant UV damage of the skin cells (epidermis/dermis)