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One of the mechanisms of differential metabolic states between M1 and M2 macrophages has been identified as a switch in the expression of phosphofructokinase 2 isoenzymes that appears to be a common event after LPS/IFN- or TLR 2, 3, 4, and 9 stimulation (M1 pathway) [48]

Over 48 weeks, 208 (54%) of 384 patients in the cladribine 3.5 mg/kg group and 222 (56%) of 396 patients in the cladribine 5.25 mg/kg group were free from disease activity versus 86 (24%) of 360 patients in the placebo group

[DOI] [PMC free article] [PubMed] [Google Scholar] 125.Ahmed F.A., Chaudhary P., Sharma S.C

Image Credit: AllaBond/Shutterstock.com How they work In double-blind trials, the treatment patients have is unknown to both patients and doctors until after the study is concluded