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Description

Once glutathione neutralises a free radical, it changes converting from its active "reduced" form (GSH) into an oxidised, "used-up" form (GSSG)

It was first cultivated about 2,500 years ago in Greece, and its a Greek word that means stalk or shoot

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sinoatrial and atrioventricular nodes AV nodal conduction (effective refractory period): prolonged Significant AV nodal depression (reduced AV transmission) Reduced Ca 2+ flux: decreased diastolic depolarization rate (phase 4 depolarization) Negative SA nodal chronotropic effect Clinical Use: Major Use: Reentrant supraventricular tachycardia Alternative drug: adenosine Verapamil or adenosine preferable to previous therapy which included: propranolol, digoxin, edrophonium (anticholinesterase), vasoconstrictor agents (arrhythmia termination by reflex -- enhancing vagal tone), cardioversion Occasionally useful: conversion of atrial flutter and fibrillation to normal sinus rhythm (NSR) Rarely useful: ventricular arrhythmias