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In a recent phase Ib clinical trial focusing on domatinostat (a dual inhibitor of LSD1/HDAC) in patients with advanced melanoma, the drug failed to enhance the efficacy of treatments targeting anti-PD-1 and cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) while unexpected severe skin toxicity was observed

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At physiological pH, GSTP binds GSH and lowers the p Ka of the thiol, producing a thiolate anion (GS - ) at the active site

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It requires a commitment on part of the patient to realize all the beneficial effects