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Yang PX, et al

doi: 10.1111/anu.13096

Research indicates that certain haplogroups, such as U, H, and J, may act as significant risk factors for AD, potentially affecting the efficiency of oxidative phosphorylation and production of reactive oxygen species (ROS) (157, 159)

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Tiss et al

Mutation of U597 to serine resulted in sustained thiolate-FAD charge transfer absorption and loss of the ability to reduce Trx, indicating that the C596-U597 disulfide functions in the catalytic sequence to receive electrons from the C154 C159 pair and distribute them to Trx