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Cancer Cell 17 , 98110 (2010)

Two reasons in the documented cadence

Succinic acid was added to the samples around 10 min before starting the assay to avoid competitive inhibition by endogenous oxaloacetate

J Plant Physiol 135:164169 Deng F, Yamaji N, Xia J, Ma JF (2013) A member of the heavy metal P-type ATPase OsHMA5 is involved in xylem loading of copper in rice

Upon exposure to sunlight, tretinoin rapidly degrades into less active or inactive metabolites , thereby reducing its therapeutic efficacy

NICE recommends more frequent injections (alternate days until no further improvement) for patients with neurological involvement