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Proc Natl Acad Sci U S A 101:1505215057 Hicks LM, Cahoon RE, Bonner ER, Rivard RS, Sheffield J, Jez JM (2007a) Thiol-based regulation of redox-active glutamate-cysteine ligase from Arabidopsis thaliana

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Up to now, powerful genetic tools allowed clarification of the significance, dispensability and potential of cystine transporters for ferroptotic cell death in PDAC and breast cancer (28)

reported that the iron-sulfur cluster (ISC) could activate IRP2, enhancing sensitivity to ferroptosis through mechanisms independent of IRP1 and FBXL5 (37)