low glutathione and gad antibodies Pro- anti-inflammatory response in neurological disorders associated to anti-glutamate decarboxylase Role of Glutathione in Cancer:

& Kaiser, C

Edwards et al., 1990)

Intracellular ROS measurement LNCaP cells were seeded at 6 10 4 cells/well in 24-well plates, adhered overnight and then incubated with conditioned media for 2.5 days before treatment with doxorubicin or taxol

This result highlights that rather than synthesizing GSH, cysteine has other downstream fates of greater importance, such as protein translation or cysteine polysulfidation 50

75 Conversely, forced overexpression of CDO1 in breast cancer cells shifted the flux from glutathione synthesis towards cysteine catabolism, consequently increasing ROS levels and leading to reduced cell viability and growth

A critical anti-oxidant function of ascorbate is in the plasma membrane reduction of oxidized -tocopherol (vitamin E)