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[DOI] [PMC free article] [PubMed] [Google Scholar] Su C

Reversibility and recurrence of IGF-IR-induced mammary tumors

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Several mechanisms for their beneficial functions were proposed including a reduction in insulin resistance, the promotion of autophagy, and an increase in the T regulatory population

Oestrogen dependence may be due to the upregulation of the 17-hydroxysteroid dehydrogenase-1 and aromatase genes, whereas progesterone resistance may result from the failure of progesterone receptor activation and transcription of progesterone target genes [99]

Therapeutic targets for treating fibrotic kidney diseases