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PMID: 41228201

2020;6(1):p

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Additionally, other investigations have shown that Wortmannin and LY294002 reduce bronchial hyperresponsiveness and eosinophilic bronchial inflammation in a mouse asthmatic paradigm [153]

The plasma concentration does not correlate with brain concentration or relief of pain

The response to an opioid analgesic varies greatly by age
