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Description
Key pharmacological effects include: Glucose-dependent insulin secretion Enhanced pancreatic beta-cell insulin release only when blood glucose is elevated, reducing hypoglycemia risk Suppression of glucagon secretion Decreased hepatic glucose production from pancreatic alpha cells Delayed gastric emptying Slowed movement of food from the stomach to the small intestine Central appetite regulation Reduced hunger and increased satiety through hypothalamic pathways The delayed gastric emptying effect is particularly significant and represents both a therapeutic mechanism and a potential source of adverse effects
Science 315 , 18171822 (2007)

So DiMarchi started creating drugs that targeted both GLP-1 and glucagon receptors

What are the main reasons to consider a GLP-1

Understanding the mechanisms underlying the anorexic effects of GLP-1 is of great interest

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