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The underlying genetic defect involves the NF1 tumor suppressor gene, resulting in loss of neurofibromin, a protein responsible for regulating cell growth and preventing uncontrolled cell proliferation

The different types of KS include: Epidemic (AIDS-related) Kaposi sarcoma Classic (Mediterranean) Kaposi sarcoma Endemic (African) Kaposi sarcoma Latrogenic (transplant-related) Kaposi sarcoma Kaposi sarcoma in HIV-negative men who have sex with men Epidemic (AIDS-related) Kaposi sarcoma develops in those who are HIV infected