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Clin Ther:46 (5): 404-410 Talebi S et al

Ngo DT, Sverdlov AL, McNeil JJ, Horowitz JD

The future of mitochondrial medicine will increasingly require therapeutic personalization based on molecular diagnosis and clinical phenotype

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The results obtained demonstrated that the use of ALA (600 mg/day) as an additional therapy to doxorubicin and paclitaxel induces a significant improvement in the peripheral sensory neuropathy grading (according to National Cancer Institute Common Terminology Criteria for Adverse Events, version 4.0) and in the FACT/GOG-Ntx-12 (12-item neurotoxicity questionnaire) total score

The concerted action of these proteins creates a carnitine network that becomes relevant in the context of cancer metabolic rewiring
