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Altering the hydrophobicity of the binding site by substituting residue V148 (V120 in dDAT NET ) in hNET to an isoleucine leads to a 17-fold enhancement of milnaciprans inhibitory potency 32

GS-conjugates are actively transported out of cells by efflux transporters including MRP1 and P-glycoprotein belonging to the superfamily of ATP-binding cassette transporters 70,71,72

Despite the progress achieved in understanding its pathophysiology, the establishment of new treatments for I/R injuries still represents a major challenge

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