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Serum holoTC is a better biomarker of recent B12 intake than serum B12 (or methymalonic acid or tHcy) because serum holoTC concentrations increase much faster after ingestion of B12 from a meal (i.e., 6 hours) or crystalline B12 from supplements

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Higher concentrations aren't necessarily better and may increase irritation risk without proportional benefits

Morphologic features of mucosal injury were based on different grades of epithelial lifting, villi denudation, and necrosis

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