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Systematic reviews of oral vitamin B12 therapy in vitamin B12 deficiency The first evidence-based analysis by the Vitamin B12 Cochrane Group in 2005 supports the efficacy of oral vitamin B12 as a curative treatment, with a dose between 1,000 and 2,000 g (1 and 2 mg) initially prescribed daily and then weekly [27]

IPR petitions are filed continuously, and the status of a patent under IPR challenge changes as institution decisions, oral arguments, and final written decisions are issued

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It is distributed rapidly to tissues with high metabolic activity like the liver, kidneys, and muscles

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