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Under normal conditions, NNMT activity can consume substantial amounts of both nicotinamide and SAM, particularly in metabolically active tissues or during periods of metabolic stress

No IGF-1 or glucose disruption: Unlike HGH, AOD-9604 does not significantly increase IGF-1 or negatively affect insulin sensitivity, making it a safer candidate for metabolic regulation

Skeletal muscle ageing models preclinical investigation has explored NNMT inhibition in models of age-related muscle dysfunction and stem-cell quiescence