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It is an immune system malfunction , a barrier defect, and a microbial imbalance happening simultaneously
Wiberg et al., 2017) atrophy

[1] Cell Line:Cultured Sprague-Dawley rat Achilles tendon fibroblasts (passages 2-4) Concentration:0, 0.5, 1, 2 g/mL Incubation Time:24 h Result:Did not alter total FAK, paxillin, or PCNA protein levels

The first group received only a nerve crush using the clip (n = 8, control group)
