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Accordingly, the ASCO and NCCN guidelines note that stimulants can be considered only for refractory CRF or when rapid improvement in fatigue is needed (e.g., to maintain work schedules), but they refrain from routine recommendation due to mixed evidence and potential side effects

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Sigma-Aldrich, Steinheim, Germany) stimulation for 69.5 h at 37C and 5% CO 2 , followed by incubation with Alamar Blue (AbD Serotec, Oxford, UK) in a ratio of 1:10 for 2.5 h