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[DOI] [PubMed] [Google Scholar] 9.Sheng J., Liu S., Qin H., Li B., Zhang X

Nat Commun 17 , 5274 (2026)

Lifestyle changes, such as diet and exercise, are also thought to be able to reduce oxidative stress levels, which in turn improve eNOS function [85]

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In IR there is impaired signaling via the phosphoinositol-3 kinase pathway allowing the buildup of toxic lipid metabolites, such as FA acyl CoA, diacylglycerol, and ceramide in numerous tissues including the liver, pancreatic beta cells, and adipocytes [81]

Williamson J, Hughes CM, Cobley JN, Davison GW