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The stratum corneum, the outer layer of skin, is a lipophilic barrier designed to keep hydrophilic molecules out

One possible contributing factor may be the increased stiffness of ocular structures (ocular rigidity) which may augment trabecular contractility (which elevates IOP) and increase the susceptibility of ganglion cells and glia to pressure-mediated stress

Retinoids present a similar conflict

It is considered an investigational compound and is typically sold by research chemical suppliers under the label for research purposes only

Lyophilised powder preserves compound integrity and allows precise reconstitution for controlled research protocols