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Gamma-glutamyl cycle and enzyme deficiencies (highlighted in red) related to different diseases (highlighted in blue)

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The antioxidant enzymes glutathioneperoxidase, catalase, and superoxide dismutase (SOD) metabolize oxidative toxic intermediates

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Involvement of the Cys1093 residue oxidation in TRPM4 channel activation has also a significant role in oxidative stress dependent (without ATP depletion) activation and desensitization of TRPM4

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