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A 2025 study published in Biogerontology demonstrated dose-dependent telomere length extension in normal human cells through upregulation of hTERT (the telomerase catalytic subunit) and telomerase enzyme activity meaning Epithalon appears to reactivate the cellular machinery that maintains telomere length rather than just slowing its shortening
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At the end of the 36-week tirzepatide lead-in period, participants achieved 21.1% mean WL
However, no differences were detected in various OS markers, including SOD, CAT, GPx, 4-HNE and carbonyls [Parry et al ., 2018]
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