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Data Availability Statement The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

Although e-cig aerosol exposure did not increase cellular inflammation, it did increase methacholine responsiveness and reduced lung volumes at fixed inflation pressures, suggesting a change in mechanical properties and/or lung size

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There is a role of oxidative stress as a cofactor of disease progression from asymptomatic human immunodeficiency virus (HIV) infection to the acquired immunodeficiency syndrome (AIDS)

Metformin is a commonly used anti-diabetic agent (121)