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To date, three patterns of p-i-related hypersensitivity reactions have been proposed: the altered peptide model of p-i HLA, the allo-immune model of p-i HLA, and the p-i TCR model ( The altered peptide model of p-i HLA and the allo-immune model of p-i HLA were both developed because some ADRs generated by small molecule drugs are limited exclusively to the HLA allele (36)

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10.1007/s00277-019-03618-w 15

Nutrition, the brain and cognitive decline: insights from epigenetics

Apoptotic markers such as caspase 3 (Cas-3), B-cell leukemia/lymphoma 2 protein (BCL-2), BCL-2-associated X protein (BAX), and cytochrome C (Cyt-C), together with endoplasmic reticulum stress markers including C/EBP homologous protein (CHOP), glucose-regulated protein 78 (GRP78), and caspase 12 (Cas-12), contribute to alveolar epithelial and endothelial damage

Results Effect of AST on short-term memory in scopolamine-induced Alzheimers model in mice: Figure 1 shows that the scopolamine-induced AD group showed a significant decrease in SAP compared to the control mice