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The C-terminal domain constitutes the substrate-binding site (H-site) and is composed of amino acid residues from the carboxyl terminus, capable of binding various substrate [10,11,12]

for others, meaningful change takes longer or doesnt materialize

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Increased inhibitory output causes increased inhibition of the thalamus, as well as reduced excitatory input to the motor cortex

These grading scales include the Ajani Sensory, Eastern Cooperative Oncology Group (ECOG), National Cancer InstituteCommon Terminology Criteria for Adverse Events (NCICTCAE), and World Health Organization (WHO) systems, which grade CIPN severity on a scale of 0 (normal) to 5 (death)

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