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10.1186/s40360-019-0326-6 84 SirabellaR.SisalliM

Influence of age and body mass index on total and segmental colonic transit times in constipated subjects

It upregulates key glycolytic enzymes (HK2, PKM2) and vascular endothelial growth factor (VEGF), promoting vascular remodeling and alveolar space enlargement, while inhibiting the proliferation and repair of alveolar epithelial cells ( 4.3 Small airway disease Small airway disease, however, serves as the primary pathological driver of airflow limitation in COPD

Concurrently, a disruption in excitatory/inhibitory (E/I) balance may occur here, potentially due to weakened function of inhibitory neurotransmitters (Olthof et al., 2022)

Unexpected applications of secondary metabolites

These situations are unusual but possible