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Thus, GSH supplementation in the DG sub-group of elderly diabetic patients over a period of 6 months led to a significant increase in the erythrocyte GSH, GSSG, and FPI and a decrease in HbA1c and 8-OHdG levels (Figure S2), suggesting that the elderly diabetic population responds better to GSH supplementation in conjunction with anti-diabetic therapy

In a 2020 study published, there were no adverse effects in single-dose studies

This includes investigating its long-term effects, optimal dosages, and administration methods

In addition, DON can inhibit cellular nucleotide production and result in cytotoxicity against AML [55]

However, over-supplementation may cause headaches, anxiety, or sleep disturbances in sensitive individuals