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SARS-CoV2 entry and spread in the lymphatic drainage system of the brain

Trait fatigue is a symptom associated with many diseases, such as multiple sclerosis, chronic obstructive pulmonary disease (COPD), and rheumatoid arthritis, and is a result of primary disease-related mechanisms as well as secondary mechanisms not directly caused by the disease but associated with it (Behrens et al., 2023)

The sex difference in serine-312 phosphorylation of IRS-1 (pSer-IRS-1) may be akin of an increased vulnerability and a more advanced stage of brain IR in women than men with MDD