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FIGURE 2 On the other hand, in addition to its well-known functions, PGC1, a master regulator of mitochondrial biogenesis, positively regulates mitophagy by directly inducing the expression of transcription factor EB (TFEB) that mediates lysosomal biogenesis (Settembre et al., 2011)

The brain has the highest content of lipids after adipose tissue [16]

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[DOI] [PubMed] [Google Scholar] 93.Regulus P., Desilets J.F., Klarskov K., Wagner J.R