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developed a three-dimensional bioprinted cardiac patch, for sustained delivery of EVs (Figure 7) (Bar et al., 2022)

According to experts, GHK has a strong affinity for copper and readily links up with it to form GHK-Cu

The compound a 15-amino-acid pentadecapeptide originally isolated from human gastric juice demonstrates unusual protease resistance combined with angiogenic and anti-inflammatory signaling

These are due to its ability to increase glutathione levels, scavenge free radicals and reduce oxidative stress

Thus, interaction of S100A12 with its specific target proteins increases pro-inflammatory immune response and induces inflammation (143)

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