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Considering the emerging reports of suppressed AGXT and impaired glyoxylate/oxalate metabolism in MASLD 12,15,16,17 , and to address the mechanisms by which oxalate promotes MASH, we studied the effects of oxalate on molecular and metabolic drivers of MASH in hepatocytes

Excess and chronic consumption of methionine-rich meals overutilizes this metabolic pathway, resulting in excess reactive oxygen species (ROS) production

Protracted oxidative stress and diminished antioxidant defenses are associated with GSH oxidation and depletion (16), a phenomenon observed in hypertensive subjects compared to non-hypertensive subjects (17)

Baki ME, Uygun H, Ari B, Aydin H

The first post-brushing mouthwash is the antiseptic Listerine

Flanagan JG, Vanderhaeghen P (2003) The ephrins and eph receptors in neural development