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We used a Mendelian randomization design to test whether this relation might be causal

Evidence suggests that the effect may be greatest for semaglutide once weekly, followed by dulaglutide and liraglutide, closely followed by exenatide once weekly, and then exenatide twice daily and lixisenatide

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Blocking NNMT restores intracellular NAD+, which fuels mitochondrial energy production and cellular repair throughout your body

The 1:1 ratio is a balance decision
