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The papain was removed, DMEM culture medium was added, and the tissue was blown to make a cell suspension

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Also, PGC-1 is found to interact with estrogen-related receptor (ERR), which is also a major contributor to mitochondrial biogenesis (Schreiber et al., 2004)

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Unfortunately, current hiPSC modeling methods fall short in accurately mimicking the interactions between the diseased cell type and other cells within the tissue or the patients body