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( l ) Immunoblot of the indicated proteins in Kuramochi cells treated olaparib (Olap) or cisplatin (Cis) alone or in combination with KG, l-carnitine, or O-acetyl-l-carnitine

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found that TMAO can inhibit the RCT process and affect cholesterol metabolism ( ApoE / mice, and further activate the nuclear receptors farnesoid-X-receptor (FXR) and small heterodimer partner (SHP), to reduce the expression of cholesterol 7-hydroxylase (Cyp7a1) to inhibit bile acid synthesis, thus accelerating the formation of atherosclerosis ( coprostanol (a bacterial metabolite of cholesterol) ( Figure 3 Potential Therapeutic Measures of TMAO for AS Reduced Production of TMAO to Protect the Heart TMAO is an intestinal microbiota-dependent metabolite, which is accumulated in the body by ingestion of large amounts of substances rich in phosphatidylcholine

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made it more paradoxical as they reported that carnitine supplementation could significantly lessen both the fatigue severity scale and mental fatigue score of hypothyroid patients younger than 50 years of age, and thus they concluded that carnitine supplementation may be useful in alleviating fatigue symptoms in this group [31]