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*Frontiers in Pharmacology*, 12, 634151

It activates protein phosphatase 2A, which removes the regulating phosphate group from the liver bifunctional enzyme, the inactivating phosphate from pyruvate kinase, and an inactivating phosphate group from a transcription factor, ChREBP (Carbohydrate Response Element Binding Protein) that activates transcription of genes for fatty acid synthesis in the liver

Thus, in the present chapter are described the pharmacodynamic and pharmacokinetic characteristics of DOACs, parameters that can help to differentiate their use based on the patients characteristics

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EBioMedicine 40, 432445