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doi: 10.4158/EP-2017-0056

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This cortisol-neutral profile is important because elevated cortisol is associated with increased appetite (particularly for high-calorie foods), abdominal fat accumulation, and metabolic complications

[106] [107] [108] [109] The serotonin releasing effects of tramadol could be blocked by sufficiently high concentrations of the serotonin reuptake inhibitor 6-nitroquipazine, which is in accordance with other serotonin releasing agents such as fenfluramine and MDMA

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