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A comprehensive approach was adopted, utilizing international scientific databases like PubMed, Scopus, and specialized resources such as ClinicalTrials.gov to assimilate the latest research findings and clinical trial data

Moreover, it was found that temozolomide-mediated cytotoxicity of glioma stem cells may be stimulated by metformin, which has a synergistic effect and may involve the inhibition of Akt phosphorylation (93, 94)

Studies demonstrate that exercise stimulates renal synthesis of ELABELA (ELA), a dual-organ protective peptide hormone

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Regulatory functions of the vascular endothelium