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Another study revealed that the mRNA levels of proinflammatory markers (IL-1, IL-6, TNF-, and lymphotoxin A) and anti-inflammatory markers (cytokine IL-10, and of IL-1 receptor antagonist (IL-1RA)) were substantially increased and decreased, respectively, in the prefrontal cortex of depressed individuals who committed suicide [67]

These data suggest that structure and sequence determine which lysine acetylation sites are accessible for enzymatic deacetylation, supporting earlier findings of our laboratory 64

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J Immunol (2009) 182(9):58009.10.4049/jimmunol.0801873 31 ZhangXWheelerDTangYGuoLShapiroRARibarTJet alCalcium/calmodulin-dependent protein kinase (CaMK) IV mediates nucleocytoplasmic shuttling and release of HMGB1 during lipopolysaccharide stimulation of macrophages

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Assimos D, Krambeck A, Miller NL, Monga M, Murad MH, Nelson CP, et al