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Infect Genet Evol 45: 474492

B12 deficiency typically has two causes: malabsorption or inadequate intake

Lipid peroxidation and its products can affect membrane function and ultimately lead to cell death

Additionally, in Alzheimer's disease models where neuronal dysfunction was induced by intracerebroventricular injection of A 142, treatment with nicotinamide (NAM) effectively prevented memory deficits (210)

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[DOI] [PubMed] [Google Scholar] 28.Shi Y., Yamada K., Liddelow S.A., Smith S.T., Zhao L., Luo W., Tsai R.M., Spina S., Grinberg L.T., Rojas J.C., et al