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For example, a high-fat diet causes down-regulates Lactobacillus enterica , which subsequently leads to decreased expressions of sodium-glucose co-transporter and glucagon-like peptide 1 (GLP1), resulting in insulin resistance and elevated blood glucose levels as well as activation of oncogenic KRAS and induction of aerobic glycolysis

doi: 10.1073/pnas.0931428100 [DOI] [PMC free article] [PubMed] [Google Scholar] 216.Simoes SM, Figueiras AR, Veiga F, Concheiro A, Alvarez-Lorenzo C
doi: 10.1039/b000222o

doi: 10.1016/j.rmed.2011.01.005

This review describes key experimental and clinical evidence that link melatonin with the etiopathology and symptomatology of depressive states, its role in the follow up of therapeutic response to antidepressants, as well as the clinical evidence of melatonin as MDD treatment

February 12, 2026