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These different cleavages are carried out by proteases, including a disintegrin and metalloproteinase (ADAM10 and ADAM 17), mainly responsible for -cut cleavage in kidney cells ( Figure 6 Klotho Regulation and GH Secretion To date, it has not been clearly established how klotho secretion is regulated, although the fact that the kidneys are the main source of klotho suggests that hormones and factors involved in mineral homeostasis play a role in this regulation