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In parallel, a number of emerging electrophysiological techniques have been developed to assess smallfiber function beyond conventional NCS, which primarily reflect largefiber integrity

Sarriera JE, Albitar M, Estrov Z, Gidel C, Aboul-Nasr R, Manshouri T, Kornblau S, Chang KS, Kantarjian H, Estey E
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Citrulline supplements actually increase arginine in the blood more than arginine itself, although this does not appear to increase NO production in healthy people with low but normal NO

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But the rate of clearance is slow enough to allow multiple pituitary passages and repeated receptor binding events