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Toxicol Ind Health 31(1):7378

S.WhitakerR

GSH is present in tissues at concentrations ranging from 1 to 10 mM and, on account of its ability to donate reducing equivalents, it is essential for both direct (chemical) and enzymatic neutralization of toxic reactive species and, in particular, for cellular defense towards oxidants [1]

30 GentilinE.SimoniE.CanditoM.CazzadorD.AstolfiL

Furthermore, mice with cardiac-specific overexpression of a mutated human B-crystallin (R120G mutant) developed protein aggregation cardiomyopathy and exhibited reductive stress in the heart as evidenced by increases in GSH levels, GSH/GSSG, and the activities of GR, G6PD, catalase, and GPx (77)