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Moreover, DEX treatment (0.5 g/kg/h, pumping injection, before induction of anesthesia to the end of surgery) has been reported to reduce cardiac troponin I and MDA levels and to decrease the incidence of arrhythmias in patients undergoing cardiac valve replacement [234, 235]
J Mol Cell Cardiol Plus 11:100278
Rajaram R, Correa AM, Xu T, Nguyen QN, Antonoff MB, Rice D, Mehran R, Roth J, Walsh G, Swisher S , Hofstetter WL, Vaporciyan A, Cascone T, Tsao AS, Papadimitrakopoulou VA, Gandhi S, Liao Z, Sepesi B
They may undergo extensive firstpass metabolism (phase II conjugation in the intestine and liver) which drastically reduces the free (unmodified) compound reaching systemic circulation
van der Heide V, Jangra S, Cohen P, Rathnasinghe R, Aslam S, Aydillo T, et al
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