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During the phenotypic transformation of VSMCs, there is a decrease in glucose oxidation and an increase in FAO

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The interplay between ferroptosis and lipid metabolism is important in anti-tumor immunity modulation

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Moreover, DOX/aNLG919-loaded CaCO 3 nanoparticles (DNCaNPs) obtained by combining the ICD inducer DOX and the IDO1 inhibitor alkylated NLG919 can induce ICD in cancer cells and can induce effective anti-tumor immune responses by inhibiting IDO1 to limit the production of immunosuppressive kynurenine thereby leading to increased tumor cytotoxic CD8 + T cell infiltration and immunosuppressive Tregs depletion, and the combination of chemotherapy and immunotherapy with this nanoparticles can effectively inhibit tumor growth (168)

J Occup Environ Med 2000;42:10761084