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Symptoms include: Lethargy Loss of appetite Weight loss Weakness Stunted growth in puppies Failure to thrive in newborn puppies Severe cobalamin deficiency can also result in neurologic symptoms, such as seizures and ataxia

Acknowledgments This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors

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The combination is studied in connective-tissue, dermal, and angiogenesis models

IschemiaReperfusion or Hypoxic Injury Models In research models of ischemic insult (e.g., engineered tissue constructs under oxygen deprivation), the blend may be relevant to evaluations of its potential to rescue microvasculature, reduce necrosis spread, or promote regenerative infiltration when reperfusion is restored