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Reduction in the activity of genes such as the one that regulates the enzyme methyl-enetetrahydrofolate reductase (MTHFR) increases mean homocysteine levels

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To conclude, in this report we have provided the first, to our knowledge, comprehensive biochemical analysis of a TGR selenoprotein from any organism , showing that it has remarkably wide substrate specificity and may be effectively inhibited by a number of low-molecular-weight compounds