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PMCID: PMC6826538 Blackburn PR, Xu Z, Tumelty KE, Zhao RW, Monis WJ, Harris KG, Gass JM, Cousin MA, Boczek NJ, Mitkov MV, Cappel MA, Francomano CA, Parisi JE, Klee EW, Faqeih E, Alkuraya FS, Layne MD, McDonnell NB, Atwal PS

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Research in Thailand reported that the incidence of MetS in patients with CKD was 71.3%, displaying an evident higher incidence than that in patients without CKD ( 2.3 The pathogenesis of MetS-related nephropathy Insulin resistance is the critical feature of MetS, and insulin receptors are expressed in podocytes, tethered cells, renal microvascular endothelial cells, and tubular epithelial cells of the kidney ( 1 (TGF- 1 ) is increased in renal inflammation and renal fibrosis, which contributes to the progression of MetS-related nephropathy ( 1 could activate the tumor suppressor p53 in diabetic insults

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The few family-based three-way interaction approaches that have been reported for ASD could not take full advantage of the family data because they were limited to multiple dimensionality reduction (MDR) methods developed for casecontrol designs (Anderson et al