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Subgroup analysis of those subjects having reduced corneal nerve fibers, and therefore more definitive evidence of small fiber neuropathy (37), show that ARA 290 treatment is associated with an increase in corneal nerve fiber density, analogous to the improvement seen after improved metabolic control (42) and after simultaneous pancreas and kidney transplantation (43)

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(398) built on these findings and demonstrated a remarkable interorgan neural circuit that utilizes intestinofugal neurons as the afferent limb of the ileal brake

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